Organotin(IV) complexes with epigenetic modulator ligands: New promising candidates in cancer therapy

Organotin(IV) compounds have found their place among a class of non-platinum chemotherapeutic metallo-pharmaceuticals exhibiting good antitumor activity. The cytotoxicity induced by the different kinds organotins has been related to several mechanism. In this review we report our last decade research activity concerning synthesis and chemical characterization new organotin(IV) derivatives containing epigenetic modulator ligand using, FT-IR, Mössbauer spectroscopy, 119Sn{1H} cross polarization magic angle spinning, electrospray ionization mass UV–Vis, 1H, 13C{1H} NMR spectroscopy density functional theory calculations. first aim biological studies was evaluate effects exerted complexes in comparison with corresponding free ligands on panel cancer cell lines, including human HepG2 hepatoma cells, HCT116 colorectal carcinoma cells MDA-MB-231 breast cells. We provide evidence that compounds, generally, exert significant cytotoxic even at nanomolar (nM) or micromolar (μM) range concentrations. also evaluated biochemical pathways underlining these coordinated form compared parental constituents.